{"id":198,"date":"2013-04-09T18:53:39","date_gmt":"2013-04-10T00:53:39","guid":{"rendered":""},"modified":"2013-04-09T19:11:14","modified_gmt":"2013-04-09T10:11:14","slug":"camp\u53d7\u5bb9\u30bf\u30f3\u30d1\u30af\u8cea\u3068dna\u306eifie map\u89e3\u6790","status":"publish","type":"post","link":"https:\/\/www.cenav.org\/kdb\/?p=198","title":{"rendered":"cAMP\u53d7\u5bb9\u30bf\u30f3\u30d1\u30af\u8cea\u3068DNA\u306eIFIE map\u89e3\u6790"},"content":{"rendered":"<h3 id=\"kdb_body\">\u6982\u8981<\/h3>\n<p>\u5927\u8178\u83cc\u306ecyclic-AMP\u53d7\u5bb9\u30bf\u30f3\u30d1\u30af\u8cea(CRP)\u3068DNA\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001IFIE map\u89e3\u6790\u3092\u884c\u3063\u305f[1,2]\u3002<\/p>\n<p class=\"rtecenter\"><img alt=\"\" src=\"\/kdb\/old\/u5\/Fig7-0_IFIE_cAMP-DNA.png\" style=\"width: 201px; height: 318px\" \/><\/p>\n<h3 id=\"kdb_field_related_modules\">\u95a2\u9023\u30e2\u30b8\u30e5\u30fc\u30eb<\/h3>\n<p>BioStation Viewer<\/p>\n<h3 id=\"kdb_field_sim_model\">\u89e3\u6790\u30e2\u30c7\u30eb<\/h3>\n<p>cyclic-AMP\u53d7\u5bb9\u30bf\u30f3\u30d1\u30af\u8cea(CRP)\u3068DNA\u8907\u5408\u4f53<\/p>\n<p>\u539f\u5b50\u65703899\u3001\u6b8b\u57fa200\u6b8b\u57fa\u300122\u5869\u57fa\u5bfe\u3001\u30ea\u30ac\u30f3\u30c91\u5206\u5b50\u3001\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u6570245<\/p>\n<p>FMO2-MP2\/6-31G<\/p>\n<h3 id=\"kdb_field_calc_condition\">\u8a08\u7b97\u6761\u4ef6<\/h3>\n<ul>\n<li>\n\t\tFMO2-MP2\/6-31G<\/li>\n<li>\n\t\t\u30a8\u30cd\u30eb\u30ae\u30fc\u4e00\u70b9\u8a08\u7b97<\/li>\n<li>\n\t\t\u771f\u7a7a\u4e2d<\/li>\n<li>\n\t\t\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u5206\u5272\uff1a\u4e3b\u9396\u5206\u5272\u3001Base\/Sugar+Phosphate<\/li>\n<li>\n\t\tESP-AOC\u8fd1\u4f3c\uff08Lptc=2.0, Laoc=0.0\uff09<\/li>\n<\/ul>\n<h3 id=\"kdb_field_exe_env\">\u5b9f\u884c\u74b0\u5883<\/h3>\n<p>CPU:<\/p>\n<p>GPU:<\/p>\n<p>Memory:<\/p>\n<p>HDD:<\/p>\n<h3 id=\"kdb_field_description_simu_case\">\u8a73\u7d30\u8aac\u660e<\/h3>\n<p>CRP\u3068DNA\u8907\u5408\u4f53\u306eFMO\u8a08\u7b97\u306fMP2\/6-31G\u30ec\u30d9\u30eb\u3067\u884c\u3044\u3001\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u5206\u5272\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u5358\u4f4d\u3001DNA\u3092\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u5358\u4f4d\u3067\u3055\u3089\u306b\u4e3b\u9396\u3068\u5869\u57fa\u90e8\u5206\u3092\u5225\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3068\u3057\u305f\u3002\u5404\u8ef8\u306f\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u756a\u53f7\u3092\u8868\u3057\u3001\u30d5\u30e9\u30b0\u30e1\u30f3\u30c81-200\u304cCRP\u3001201-244\u304cDNA\uff08\u524d\u534a\u304c\u5869\u57fa\u90e8\u5206\u3001\u5f8c\u534a\u304c\u4e3b\u9396\u90e8\u5206\uff09\u3001245\u304c\u30ea\u30ac\u30f3\u30c9(cMAP)\u3067\u3042\u308b\u3002\u5bfe\u89d2\u7dda\u306e\u4e0a\u5074\u306b\u5f15\u529b\u7684\u306a\u76f8\u4e92\u4f5c\u7528\uff08\u8d64\u8272\uff09\u3001\u4e0b\u5074\u306b\u53cd\u767a\u7684\u306a\u76f8\u4e92\u4f5c\u7528\uff08\u9752\u8272\uff09\u304c\u8868\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u90e8\u5206\u3067\u306f\u3001&alpha;\u30d8\u30ea\u30c3\u30af\u30b9\u304c\u5bfe\u89d2\u7dda\u306b\u4e26\u884c\u3001&beta;\u30b7\u30fc\u30c8\u304c\u5782\u76f4\u306a\u6a21\u69d8\u306e\u3088\u3046\u306b\u898b\u3048\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u306f\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u9593\u306b\u50cd\u304f\u6c34\u7d20\u7d50\u5408\u306e\u30d1\u30bf\u30fc\u30f3\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002DNA\u306e\u5869\u57fa\u90e8\u5206\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306b\u3001\u30b9\u30bf\u30c3\u30ad\u30f3\u30b0\u76f8\u4e92\u4f5c\u7528\u304c\u5bfe\u89d2\u7dda\u3068\u4e26\u884c\u3001Watson-Crick\u6c34\u7d20\u7d50\u5408\u304c\u5bfe\u89d2\u7dda\u3068\u5782\u76f4\u306a\u76f8\u4e92\u4f5c\u7528\u30d1\u30bf\u30fc\u30f3\u3068\u3057\u3066\u898b\u3048\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p class=\"rtecenter\">&nbsp;<img alt=\"\" src=\"\/kdb\/old\/u5\/Fig7-1_IFIE-MAP_cAMP-DNA.png\" style=\"width: 500px; height: 472px\" \/><\/p>\n<p class=\"rtecenter\"><strong>\u56f31. DNA\uff0d\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306b\u304a\u3051\u308bIFIE map\u8868\u793a<\/strong><\/p>\n<h3 id=\"kdb_field_reference_info\">\u53c2\u8003\u6587\u732e<\/h3>\n<ol>\n<li>\n\t\tK. Fukuzawa, Y. Komeiji, Y. Mochizuki, A. Kato, T. Nakano, S. Tanaka &ldquo;Intra- and intermolecular interactions between cyclic-AMP receptor protein and DNA: Ab initio fragment molecular orbital study&rdquo; J. Comp. Chem.Vol. 27, pp 948-960 (2006).<\/li>\n<li>\n\t\tI. Kurisaki, K. Fukuzawa, Y. Komeiji, Y. Mochizuki, T. Nakano, J. Imada, A. Chmielewski, S. M. Rothstein, H. Watanabe, S. Tanaka &ldquo;Visualization analysis of inter-fragment interaction energies of CRP-cAMP-DNA complex based on the fragment molecular orbital method&rdquo; Bioph. Chem. Vol. 130, pp 1-9 (2007).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u6982\u8981 \u5927\u8178\u83cc\u306ecyclic-AMP\u53d7\u5bb9\u30bf\u30f3\u30d1\u30af\u8cea(CRP)\u3068DNA\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001IFIE map\u89e3\u6790\u3092\u884c\u3063\u305f[1,2]\u3002 \u95a2\u9023\u30e2\u30b8\u30e5\u30fc\u30eb BioStation Viewer \u89e3\u6790\u30e2\u30c7\u30eb cyclic-AMP\u53d7\u5bb9\u30bf [<a title=\"\u4f1a\u54e1\u767b\u9332\u304c\u5fc5\u8981\u3067\u3059\" href=\"https:\/\/www.cenav.org\/kdb\/?p=198\">\u5168\u6587\u3092\u8aad\u3080<\/a>]<\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[102,104],"tags":[],"_links":{"self":[{"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=\/wp\/v2\/posts\/198"}],"collection":[{"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=198"}],"version-history":[{"count":0,"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=\/wp\/v2\/posts\/198\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cenav.org\/kdb\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}