\u6771\u4eac\u5927\u5b66\u751f\u7523\u6280\u8853\u7814\u7a76\u6240 \u9769\u65b0\u7684\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08\u4ee5\u4e0b \u9769\u65b0\u30bb\u30f3\u30bf\u30fc\uff09\u306f\u3001\u6b21\u306e\u6761\u4ef6\u3084\u5236\u9650\u306e\u3082\u3068\u3067\u3001\u9769\u65b0\u30bb\u30f3\u30bf\u30fc\u3067\u7ba1\u7406\u30fb\u516c\u958b\u3059\u308b\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7b49\u306b\u3088\u308b\u6210\u679c\u7269\u306e\u5168\u3066\u307e\u305f\u306f\u4e00\u90e8\u3092\u7121\u511f\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u3092\u8a31\u8afe\u3057\u307e\u3059\u3002<\/p>\n
\uff11\uff0eCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u5b9a\u7fa9
\n\u9769\u65b0\u30bb\u30f3\u30bf\u30fc\uff08CISS\uff09\u3067\u7ba1\u7406\u3057\u3066\u3044\u308b\u30bd\u30fc\u30b9\u30d7\u30ed\u30b0\u30e9\u30e0\u3001\u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u30d7\u30ed\u30b0\u30e9\u30e0\u3001\u4ed5\u69d8\u66f8\u3001\u8a2d\u8a08\u66f8\u3001\u30c7\u30fc\u30bf\u3001\u5b9f\u884c\u7d50\u679c\u3000\u304a\u3088\u3073\u3000\u30de\u30cb\u30e5\u30a2\u30eb\u306a\u3069\u306e\u5185\u3001\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u4e0a\u306b\u516c\u958b\u3057\u3066\u3044\u308b\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n
\uff12\uff0e\u7121\u511f\u4f7f\u7528\u306e\u7bc4\u56f2
\n\u5229\u7528\u8005\u304cCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u7121\u511f\u3067\u4f7f\u7528\u3067\u304d\u308b\u884c\u70ba\u306b\u306f\u3001\u81ea\u5df1\u306e\u305f\u3081\u306bCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4efb\u610f\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u5b9f\u884c\u3059\u308b\u884c\u70ba\u3001\u305d\u306e\u7d50\u679c\u3092\u5229\u7528\u8005\u306e\u81ea\u5df1\u306e\u305f\u3081\u306b\u4f7f\u7528\u3059\u308b\u884c\u70ba\u3001CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u8907\u88fd\u3057\u9812\u5e03\u3059\u308b\u884c\u70ba\u3001\u304a\u3088\u3073\u3001CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u6539\u5909\u3057\u305d\u308c\u3092\u5b9f\u884c\u3059\u308b\u884c\u70ba\u7b49\u3092\u542b\u307f\u307e\u3059\u3002<\/p>\n
\uff13\uff0e\u6539\u5909\u30fb\u9812\u5e03\u3067\u306e\u9075\u5b88\u4e8b\u9805
\nCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u5909\u66f4\u3057\u305f\u308a\u3001\u4ed6\u306e\u30bd\u30d5\u30c8\u306b\u7d44\u307f\u8fbc\u3080\u7b49\u306e\u884c\u70ba\u306b\u3088\u308a\u3001\u6539\u5909\u3057\u305fCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u8907\u88fd\u30fb\u9812\u5e03\u3059\u308b\u5834\u5408\u306f\u3001\u305d\u306e\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u540d\u306b\u306fCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u540d\u79f0\u3092\u6b8b\u3057\u3066\uff08\u4f8b\u3048\u3070\u3001CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u540d\u79f0\u3092ProteinDF\u3068\u3057\u305f\u5834\u5408\u3001\u25cb\u25cb\u25cb\uff0fProteinDF\u306e\u3088\u3046\u306b\u30cd\u30fc\u30df\u30f3\u30b0\uff09\u4e0b\u3055\u3044\u3002\u305f\u3060\u3057\u5225\u9014\u55b6\u5229\u76ee\u7684\u306e\u5834\u5408\u306b\u304a\u3051\u308b\u5b9f\u65bd\u8a31\u8afe\u5951\u7d04\u3092\u7de0\u7d50\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3053\u306e\u9650\u308a\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u8457\u4f5c\u6a29\u8868\u793a\u3092\u884c\u3046\u3053\u3068\u3092\u7fa9\u52d9\u3065\u3051\u307e\u3059\u3002
\n\u76ee\u7684\u306e\u5982\u4f55\u3092\u554f\u308f\u305a\u3001CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u5185\u90e8\u30b3\u30fc\u30c9\u306e\u300e\u8457\u4f5c\u6a29\u8868\u793a\u300f\u8a18\u8f09\u90e8\u5206\u3092\u4fee\u6b63\u3059\u308b\u884c\u70ba\u306f\u3001\u6539\u5909\u8005\u6c0f\u540d\u3084\u6539\u5909\u65e5\u6642\u306a\u3069\u306e\u6539\u5909\u8a18\u9332\u3092\u8ffd\u52a0\u3059\u308b\u5834\u5408\u3092\u9664\u304d\u3001\u7981\u6b62\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n
\uff14\uff0e\u8457\u4f5c\u6a29\u306e\u8868\u793a
\n\u5229\u7528\u8005\u306f\u3001\u5404\u3005\u306eCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u8907\u88fd\u7269\u306b\u3001\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u540d\u30fb\u30d0\u30fc\u30b8\u30e7\u30f3\u30fb\u8457\u4f5c\u8005\u6c0f\u540d\u306a\u3069\u306e\u8457\u4f5c\u6a29\u8868\u793a\u3092\u8868\u793a\u306e\u5148\u982d\u90e8\u7b49\u306e\u7b87\u6240\u306b\u9069\u5207\u304b\u3064\u76ee\u7acb\u3064\u3088\u3046\u306b\u63b2\u8f09\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u9812\u5e03\u3059\u308b\u5834\u5408\u306f\u3001\u8907\u88fd\u7269\u306b\u672c\u8a31\u8afe\u6761\u4ef6\u306e\u5168\u6587\u3092\u305d\u306e\u307e\u307e\u6dfb\u4ed8\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n
\uff15\uff0e\u5229\u7528\u8005\u7fa9\u52d9
\nCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u5229\u7528\u3057\u305f\u7d50\u679c\u3092\u516c\u8868\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u95a2\u9023\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7b49\u306e\u6210\u679c\u3092\u5229\u7528\u3057\u305f\uff08\u4f8b\uff1a\u300e\u9769\u65b0\u7684\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u7814\u7a76\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u6210\u679c\u3092\u5229\u7528\u3057\u305f\u300f\uff09\u65e8\u3092\u3001\u4f7f\u7528\u3057\u305fCISS\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u540d\u524d\u3001\u30d0\u30fc\u30b8\u30e7\u30f3\u3001\u8457\u4f5c\u8005\u6c0f\u540d\u306a\u3069\u306e\u8a18\u8f09\u3068\u3068\u3082\u306b\u3001\u660e\u793a\u3057\u3066\u4e0b\u3055\u3044\u3002
\n\u5229\u7528\u8005\u304cCISS\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u6539\u5909\u3057\u3001\u305d\u306e\u5b9f\u884c\u7d50\u679c\u3092\u516c\u8868\u3059\u308b\u5834\u5408\u306f\u3001\u6539\u5909\u5185\u5bb9\u3084\u6539\u5909\u5c65\u6b74\u304c\u7279\u5b9a\u3067\u304d\u308b\u8aac\u660e\u3092\u6dfb\u4ed8\u3057\u3066\u516c\u8868\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002
\n\u5229\u7528\u8005\u304cCISS\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u30d0\u30b0\u3084\u4e0d\u5177\u5408\u3092\u767a\u898b\u3057\u305f\u5834\u5408\u3001\u9769\u65b0\u30bb\u30f3\u30bf\u30fc\u306b\u5831\u544a\u3057\u3066\u4e0b\u3055\u3044\u3002\u767a\u898b\u3057\u305f\u30d0\u30b0\u3084\u4e0d\u5177\u5408\u3092\u8a31\u53ef\u306a\u304f\u516c\u8868\u3057\u305f\u308a\u3001\u7b2c\u4e09\u8005\u306b\u77e5\u3089\u305b\u308b\u3053\u3068\u3092\u7981\u6b62\u3057\u307e\u3059\u3002<\/p>\n
\uff16\uff0e\u55b6\u5229\u76ee\u7684\u306b\u4f7f\u7528\u3059\u308b\u5834\u5408
\n\u5229\u7528\u8005\u306f\u3001CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4e0b\u8a18(1)\uff5e(3)\u306b\u4f8b\u793a\u3059\u308b\u3088\u3046\u306a\u55b6\u5229\u76ee\u7684\u306b\u4f7f\u7528\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u4e8b\u524d\u306b\u5225\u9014\u55b6\u5229\u76ee\u7684\u306e\u5834\u5408\u306b\u304a\u3051\u308b\u5b9f\u65bd\u8a31\u8afe\u5951\u7d04\u3092\u7de0\u7d50\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002
\n(1)\u5229\u7528\u8005\u304cCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u8907\u88fd\u30fb\u9812\u5e03\u3059\u308b\u5834\u5408\u3001\u8457\u4f5c\u7269\u3068\u3057\u3066\u306e\u5bfe\u4fa1\u306e\u307f\u306a\u3089\u305a\u3001\u8907\u88fd\u306a\u3044\u3057\u9812\u5e03\u306b\u5fc5\u8981\u306a\u7d4c\u8cbb\u306a\u3069\u7d4c\u6e08\u7684\u4fa1\u5024\u3092\u3001\u9812\u5e03\u3092\u53d7\u3051\u308b\u8005\u306b\u5bfe\u3057\u3066\u63d0\u793a\u306a\u3044\u3057\u8981\u6c42\u3059\u308b\u3053\u3068\u3002
\n(2)\u6cd5\u4eba\u3092\u542b\u307f\u5229\u7528\u8005\u306f\u3001\u81ea\u5df1\u306e\u76ee\u7684\u306b\u9650\u308aCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u5b9f\u884c\u304c\u8a31\u8afe\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u6709\u511f\u7121\u511f\u3092\u554f\u308f\u305a\u7b2c\u4e09\u8005\u3078\u306e\u30b5\u30fc\u30d3\u30b9\u306e\u305f\u3081\u306bCISS\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u5b9f\u884c\u3059\u308b\u884c\u70ba\u3092\u3059\u308b\u3053\u3068\u3002
\n(3)\u5229\u7528\u8005\u306f\u3001\u81ea\u5df1\u304c\u6539\u5909\u3057\u305f\u90e8\u5206\u3082\u542b\u307f\u3001CISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u8cea\u6a29\u3084\u62c5\u4fdd\u306a\u3069\u3001\u3044\u304b\u306a\u308b\u5546\u53d6\u5f15\u306e\u5bfe\u8c61\u306b\u52a0\u3048\u308b\u3053\u3068\u3002
\n\u305f\u3060\u3057\u3001\u516c\u7684\u6a5f\u95a2\u304c\u5f53\u8a72\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u666e\u53ca\u4fc3\u9032\u3092\u76ee\u7684\u3068\u3057\u3066\u305d\u308c\u3092\u5229\u7528\u3057\u305f\u30b5\u30fc\u30d3\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u5834\u5408\u306f\u3001\u305d\u306e\u30b5\u30fc\u30d3\u30b9\u306e\u6709\u511f\u7121\u511f\u3092\u554f\u308f\u305a\u3001\u5225\u9014\u305d\u306e\u5185\u5bb9\u306b\u95a2\u3057\u3066\u9769\u65b0\u30bb\u30f3\u30bf\u30fc\u3068\u306e\u9593\u3067\u899a\u66f8\u7b49\u3092\u4ea4\u308f\u3059\u3053\u3068\u3092\u3082\u3063\u3066\u55b6\u5229\u76ee\u7684\u7528\u5b9f\u65bd\u8a31\u8afe\u5951\u7d04\u7de0\u7d50\u306e\u4ee3\u7528\u3068\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3082\u306e\u3068\u3057\u307e\u3059\u3002
\n\u5229\u7528\u8005\u304c\u672c\u9805\u306b\u53cd\u3059\u308b\u884c\u70ba\u3092\u884c\u3063\u305f\u5834\u5408\u306b\u306f\u3001\u5404\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u7b49\u306e\u8457\u4f5c\u6a29\u8005\u306b\u3088\u308a\u305d\u306e\u5229\u7528\u3092\u5dee\u3057\u6b62\u3081\u3089\u308c\u308b\u3053\u3068\u3092\u5229\u7528\u8005\u306f\u4e88\u3081\u4e86\u89e3\u3057\u307e\u3059\u3002\u304b\u3064\u3001\u5229\u7528\u8005\u306f\u3001\u305d\u308c\u306b\u3088\u308a\u5f97\u305f\u5229\u76ca\u76f8\u5f53\u984d\u306e\u8ce0\u511f\u3092\u3082\u3068\u3081\u3089\u308c\u308b\u3053\u3068\u3082\u4e88\u3081\u4e86\u89e3\u3057\u307e\u3059\u3002<\/p>\n
\uff17\uff0e\u7121\u4fdd\u8a3c
\nCISS\u30d5\u30ea\u30fc\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306f\u3001\u305d\u306e\u54c1\u8cea\u3084\u6027\u80fd\u3042\u308b\u3044\u306f\u5b9f\u884c\u7d50\u679c\u306b\u3064\u3044\u3066\u3001\u5229\u7528\u8005\u306b\u5bfe\u3057\u3066\u306f\u3044\u304b\u306a\u308b\u4fdd\u8a3c\u3082\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u5229\u7528\u8005\u306f\u81ea\u5df1\u306e\u8cac\u4efb\u306b\u304a\u3044\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u306b\u540c\u610f\u3059\u308b\u3053\u3068\u3068\u3057\u3001\u3082\u3057\u4f7f\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u640d\u5bb3\u304c\u751f\u3058\u305f\u5834\u5408\u306b\u306f\u3001\u7b2c\u4e09\u8005\u3078\u306e\u640d\u5bb3\u3084\u88ab\u5bb3\u306e\u4fee\u5fa9\u3082\u542b\u307f\u3001\u305d\u306e\u7d50\u679c\u8cac\u4efb\u306f\u5168\u3066\u5229\u7528\u8005\u306b\u5e30\u3059\u308b\u3053\u3068\u3068\u3057\u307e\u3059\u3002<\/p>\n
\uff18\uff0e\u5229\u7528\u8005\u304c\u672c\u4f7f\u7528\u8a31\u8afe\u6761\u4ef6\u306b\u9055\u53cd\u3057\u305f\u5834\u5408
\n\u5229\u7528\u8005\u304c\u672c\u4f7f\u7528\u8a31\u8afe\u6761\u4ef6\u306b\u9055\u53cd\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u5229\u7528\u8005\u306f\u3001\u9769\u65b0\u30bb\u30f3\u30bf\u30fc\u304c\u305d\u306e\u72b6\u614b\u3092\u662f\u6b63\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3068\u8a8d\u3081\u3066\u884c\u3046\u63aa\u7f6e\u306b\u7121\u6761\u4ef6\u306b\u5f93\u3046\u3082\u306e\u3068\u3057\u307e\u3059\u3002<\/p>\n
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